Liquid layout vs. fixed pixel layout for professional company

[webmastero]

Hello.

Designing a site for a business that will have a lot of reach. Analysis of current stats show most every screen resolution imaginable.

The choices:
1) Liquid design - CSS with percentage based layout
2) Fixed Pixel layout - CSS with pixel based layout

What thoughts do you have on a liquid layout vs. a fixed pixel layout?
If in favor of fixed pixel layout, what width would you use for the main page?

Also, if you have a different alternative or highly advanced solution, I am all for it. I am versed in most languages (PHP, AJAX, etc.).

Thanks.

[king83]

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